Helen Turner

Helen Turner, Ph.D

hturner@chaminade.edu

Wesselkamper Science Center Room 116
Tel (808) 739-8399

3140 Waialae Ave, Honolulu, HI 96816

Professor of Biology
Dean, Natural Sciences and Mathematics Biology

Dr. Helen TurnerJoint Appointment: Non-compensated Professor, Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii
Dean of the Division of Natural Sciences and Mathematics, Dr. Turner is an internationally-regarded researcher in molecular immunology. As well as her position at Chaminade, she holds academic affiliations with the John A. Burns School of Medicine and Department of Microbiology at the University of Hawaii, and serves on numerous scientific advisory boards. She collaborates with an extensive network of scientists nation-wide, and has trained numerous graduate students for careers as biomedical investigators, science administrators and academics. Previous to her Chaminade appointment, she was an Associate Director of Research at The Queen's Center for Biomedical Research in Honolulu.

Training: Dr. Turner trained at the Imperial Cancer Research Fund Laboratories, and received her Ph.D. from the University of London in 1998. Following a post-doctoral period at the Beth Israel Medical Center and Harvard Medical School, she assumed her position at Queens in 2000.

Research: While at Queens, Dr Turner was head of a team of 10 scientists, whose efforts centered around the biology of mast cells. These immunocytes are central to inflammatory responses and are key players in pathologies such as asthma, eczema and multiple sclerosis.

Current projects in the Turner laboratory focus on mast cell ion channels as novel targets for therapeutic intervention in inflammatory pathologies, and on the molecular mechanisms by which cannabinoid compounds act as modulators of the immune system. Dr Turner's relatively young laboratory has been strikingly successful at winning grants from private foundations (The Leahi Fund for Pulmonary Research, The Victoria and Bradley Geist Foundation, The Culpeper Biomedical Pilot Initiative, and the Queen Emma Research Foundation), and from Federal sources (National Institute of General Medical Sciences, National Institute of Allergic and Inflammatory Disease, and the Idea Network for Biomedical Research Excellence). In addition to her efforts in seeking funding for her own program, Dr Turner acts as an invited grant reviewer for the NIH, the British Welcome Trust, and several other funding bodies.

Education

B. Sc. (Hons), Biochemistry, University of York, U.K.
Ph.D., Immunology, University of London, U.K.
Post-doctoral Fellow (1998-2000) Beth Israel Deaconess Medical Center and Harvard Medical School

Teaching

Directed Senior Research

Research Topics

Immunology, Mast Cell Physiology
Istlab Website

Professional Service

2003- Chair, Rhodes Scholar Selection Committee for the State of Hawaii.

2006- Chair, Scientific Advisory Board, The Tilker Medical Research Foundation.

10/2004 Ad hoc reviewer, NIH Study Section, Cellular and Molecular Immunology-A, Washington D.C.

2/2005 Ad hoc reviewer, NIH Study Section, Cellular and Molecular Immunology-A, Washington D.C.

6/2005 Ad hoc reviewer, NIH Study Section, MOSSD12, Bethesda, MD. 6/2006 Ad hoc reviewer, NIH Study Section, Cellular and Molecular Immunology-A, Washington D.C.

7/2006 Ad hoc reviewer, NIH Study Section, ZRG IMM-A1, Washington D.C.
2005 Guest Editor, Special edition on TRP Channels, Seminars in Cell and Developmental Biology.

2005 Grant Reviewer, National Medical Research Council of Singapore.
2005, 2006 Grant Reviewer, The Wellcome Trust for Biomedical Sciences.
2006- Grant Reviewer, Dutch Cancer Society.

Publications

Turner, H., Reif, K., Rivera, J. and Cantrell, D.A. (1995) Regulation of the adapter molecule Grb2 by the FcεRI in the mast cell line RBL2H3. J Biol Chem 270, 9500-9506.

Osman, N., Lucas S., Turner, H., and Cantrell, D.A. (1995) A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor ξ chain tyrosine based activation motif. J.Biol Chem 270, 13981-13986.

Osman, N., Turner, H., Lucas, S., Reif, K. and Cantrell, D.A. (1996) The protein interactions of the Immunoglobulin receptor family Tyrosine-based Activation Motifs present in the T cell receptor ζ subunits and the CD3 γ, δ and ε chains. Eur J Immunol 26, 1063-1068.

Turner, H. and Cantrell, D.A. (1997) Distinct Ras effector pathways are involved in FcεRI regulation of the transcriptional activity of Elk-1 and NFAT in mast cells. J Exp Med 185, 43-53.

Turner, H., Gomez, M., McKenzie, E., Kirchem, A., Lennard, A. and Cantrell, D.A. (1997) Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to FcεRI stimulation of mast cells. J Exp Med 188, 527-537.

Turner, H and Kinet JP. (1999) Signaling through FceRI. Nature 402:B24-B30. review.

Adra, C. N., Donato, J. L., Badovinac, R., Syed, F., Kheraj, R., Cai H., Moran, C., Kolker, M. T., Turner, H., Weremowicz, S., Shirakawa, T., Morton C. C., Schnipper L. E. and Drews, R. (2000) SMARCAD1, a novel human helicase family-defining member associated with genetic instability: cloning, expression, and mapping to 4q22-q23, a band rich in breakpoints and deletion mutants involved in several human diseases. Genomics 69, 162-173

Nadler, M.N., Matthews, S. A., Turner, H. and Kinet J. P. (2001). Signal transduction by the high affinity IgE receptor. Adv Immunol 76, 325-355. Review.

Guerrero, AP., Hishinuma, ES., Lee, TG, Bell, CK., Yuen, N., Kurahara, D., Turner, H., Stokes, A. and Andrade NN. (2003). Demographic and Clinical Characteristics of Adolescents with Obsessive-Compulsive Disorder in Hawai`I. Archives of Pediatric and Adolescent Psychiatry. 157: 665-70.

Turner, H., Fleig, A., Stokes, A., Kinet, JP., and Penner, R. (2003) Intracellular calcium release activity of VR-1 gates a specific intracellular calcium store. Biochemical Journal. 371:341-50 Samson, M-T., Small-Howard, A.L., Shimoda, L.M.N., Stokes, A., and Turner, H. (2003) Differential signaling by the CB1 and CB2 cannabinoid receptors in mast cells. J Immunol. 170(10):4953-62.

Barnhill, J., Stokes, A., Shimoda, L.M. N., Adra, C.N., Muraguchi, A., and Turner, H. (2004) RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J. Cell Biochem. 91: 808-20.

Stokes AJ, Shimoda LM, Koblan-Huberson M, Adra CN, Turner, H. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. (2004). J Exp Med. 200(2):137-47.

Stokes AJ, Wakano C, Del Carmen KA, Koblan-Huberson M, Turner, H. Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. (2004) J Cell Biochem. 94: 669-683.

Small-Howard, A. and Turner, H. Exposure to tobacco-derived materials induces over- production of secreted proteinases in mast cells. (2005). Toxicology and Applied Pharmacology. 204: 152-63.

Small-Howard A. and Turner H. Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells. (2005). Biochemical Journal. 388: 465-473.

Chinami M, Yano Y, Yang X, Salahuddin S, Moriyama K, Shiroishi M, Turner H, Shirakawa T, Adra CN. (2005) Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. J Biol Chem. 280(17):17235-42.

Kutok JL, Yang X, Folkerth RD, Imitola J, Raddassi K, Yano Y, Salahuddin S, Lawitts J, Imboden H, Chinami M, Shirakawa T, Turner H, Khoury S, Sayegh MH, Scadden D, Adra C. (2005) The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. J Mol Histol. 36(1-2):77-87.

Stokes, A.J., Shimoda. LMN, Lee, JW, Rillero, C, Chang YT and Turner, H. (2006). FceRI control of Ras in mast cells via inositol (1,4,5) trisphosphate 3-kinase and InsP4. Cellular Signaling. 18: 640-51.

Stokes, A.J., Wakano, C., Koblan-Huberson, M., and Turner, H. (2006). TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD in mast cells. Cellular Signaling. 18:1584- 1594.

Turner, H., del Carmen, K., and Stokes, A.J. (2006). TRPV cation channels in mast cells. in Handbook of Experimental Pharmacology: TRP Channels. Veit Flockerzi and Bernd Nilius, Eds. In press. Review.

Vig, M., Peinelt, C., Beck, A., Koomoa D.L., Rabah, D., Koblan-Huberson, M., Kraft, S., Turner, H., Fleig, A., Penner, R., Kinet, J.P. (2006) CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 312: 1220-3.

Small-Howard, A., Shimoda, L.M.N., Chang, Y.T., Turner, H., and Stokes A.J. Calcium dependent transcriptional programs in mast cells: inositol (1,4,5) trisphosphate 3-kinase is a store-operated gene. Submitted.

Del Carmen, K., Shimoda, L.M, Kuhn, M., Stokes, A., and Turner , H., Secretagogue-mediated coupling to the RAS by TRPV1 in cardiac mast cells. submitted.

Prasad, P., Yanagihara, A.., Turner , H. and Stokes, A. Secretogranin III directs secretory vesicle biogenesis in mast cells. submitted.