Alex Stokes

Alexander Stokes, Ph.D

alexander.stokes@chmainade.edu
astokes@hawaii.edu

Henry Hall 123C
Tel (808) 739-8373

3140 Waialae Ave, Honolulu, HI 96816

Assistant Professor of Biology

Joint Appointment: Research Assistant Professor, Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii

Education


Teaching

BI490, BI495, BI499

Research Topics

Immunology and Cardiovascular Research.

Publications

Haworth K, Shu KK, Stokes, A.J, Morris R, Stoker A. The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush. Mol Cell Neurosci. 1998 Oct;12(3):93-104.

Nadler, M. J. S., Hermosura, M. C., Inabe K., Perraud, A.-L., Zhu, Q., Stokes, A., Kurosaki, T., Kinet, J.-P., Penner, R., Scharenberg A. M. & Fleig, A. (2001) LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability. Nature 411, 590-595.

Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes, A.J, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM. (2001) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411(6837):595-9.

Guerrero AP, Hishinuma ES, Andrade NN, Bell CK, Kurahara DK, Lee TG, Turner H, Andrus J, Yuen NY, Stokes AJ. (2003). Demographic and Clinical Characteristics of Adolescents with Obsessive-Compulsive Disorder in Hawai`I. Archives of Pediatric and Adolescent Psychiatry. Jul;157(7):665-70.

Turner, H., Fleig, A., Stokes, A., Kinet, JP., and Penner, R. (2003) Intracellular calcium release activity of VR-1 gates a specific intracellular calcium store. Biochemical Journal. 371:341-50.

Samson, M-T., Small-Howard, A.L., Shimoda, L.M.N., Stokes, A.J., and Turner, H. (2003) Differential signaling by the CB1 and CB2 cannabinoid receptors in mast cells.J Immunol. 170(10):4953-62.

Barnhill, J.*, Stokes, A.J*., Shimoda, L.M. N., Adra, C.N., Muraguchi, A., and Turner, H. (2004) RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J. Cell Biochem. 91: 808-20. *co-authors.

Stokes, A.J, Shimoda LM, Koblan-Huberson M, Adra CN, Turner, H. A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. (2004). J Exp Med. Jul 19;200(2):137-47.

Stokes, A.J, Wakano C, Del Carmen KA, Koblan-Huberson M, Turner, H. Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. (2004) J Cell Biochem.91: 808-820.

Stokes, A.J., Shimoda. LMN, Lee, JW, Rillero, C, Chang YT and Turner, H. (2005). FceRI control of Ras in mast cells via inositol (1,4,5) trisphosphate 3-kinase and InsP4. Cellular Signaling. 16:640-51.

Stokes, A.J., Wakano, C., Koblan-Huberson, M., and Turner, H. (2005). TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD in mast cells. Cellular Signaling. 18: 1584-94.

Turner, H., del Carmen, K., and Stokes, A.J. (2006). TRPV cation channels in mast cells. in Handbook of Experimental Pharmacology: TRP Channels. Veit Flockerzi and Bernd Nilius, Eds.

Cheng, H., Beck, A., Launay, P., Gross, A., Stokes, A.J., Kinet, J-P., Fleig A., and Penner. R. TRPM4 controls insulin secretion in pancreatic beta cells. Cell Calcium. Jan (2007) 41(1):51-61.

Prasad, P., Yanagihara, A., Small-Howard, A.L., Turner, H., and Stokes, A.J. Secretogranin III controls secretory vesicle biogenesis in mast cells and interacts with the TRPA1 channel. Journal of Immunology V181 / No. 7 / Oct 1, 2008.

Buckley C.L, and Stokes A.J. (2011) Corin-deficient W-sh mice poorly tolerate increased cardiac afterload. Regulatory Peptides. Regul Pept. 2011 Dec 10;172(1-3):44-50. Epub 2011 Sep 6.